You cannot spawn in Louisville but you can get there by following the river towards the east direction of the Project Zomboid map.

Louisville Map

  1. Police Station
  2. Gun Store
  3. Military Checkpoint

Louisville is the largest city in the vanilla Project Zomboid map. It has multiple Police Stations, Gun Stores and plenty of points of interest to loot and explore. However to enter the city you must pass its military checkpoint.

West Point is the closest spawn to Louisville, you’ll generally have to pass it on your way to Louisville if you spawn in any other location.